Pinta is a free, Open Source drawing/editing program modeled after Paint.NET. Its goal is to provide users with a simple yet powerful way to draw and manipulate images on Linux, Mac, and Windows.
Imagine is a free image-animation viewer developed as an alternative to many other free popular viewers such as IrfanView, XnView, or FastStone Image Viewer.
PaintOkay is a streamlined and efficient alternative to the traditional MS Paint XP. It prioritizes pixel-editing functionality, allowing you to focus on precise image manipulation without the distraction of nonessential features.
ibis Paint offers a wide range of advanced features designed to enhance your digital art creation experience, making it easier to produce stunning artwork.
darktable is an Open Source photography workflow application and raw developer intended to be a virtual light table and darkroom for photographers. Portable version is also available.
GIMP Portable is the full-featured image and photo editor bundled with a PortableApps.com launcher as a portable app so that you can edit your photos and images on the go. The latest installer is available for download here.
LibreCAD is an Open Source 2D CAD (computer-aided drafting) application that provides an easy-to-use graphics suite for all major operating systems. LibreCAD portable is also available.